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Animal studies have observed increases in lifespan in the presence of elevated spermidine

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Positron emission tomography (PET) imaging reveals abnormally reduced glucose metabolism in multiple brain regions of AD patients, which correlates with the disease severity (Alexander et al., 2002)

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BHB also binds to at least two cell-surface receptors, HCAR2 and FFAR3 (reviewed in [2])
