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Using the arginine deiminase analog ADI-PEG-20 in hepatocellular carcinoma and glioblastoma has demonstrated antitumor activity in vitro and in xenograft models and demonstrated safety and efficacy in a phase I clinical trial
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Emerging evidence indicates that it is particularly associated with iron overload in the brain, especially in the hippocampus (Liu et al., 2020)

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B12 injections allow for easy absorption, a rapid increase of B12 levels within the bloodstream, and restoration of B12 levels within cells