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10.1046/j.1365-313X.1997.12040731.x Plant J
In this reaction, deprotonated GSH bound to the G-site of the enzyme induces a nucleophilic substitution of the bond between the two oxygen atoms of the hydroperoxyl group (R-OOH), leading to the release of GSOR and an OH group that is protonated into H 2 O

The primary difference comes down to absorption and bioavailability

Front Immunol 13:984678

ROS accumulation in ferroptosis We next studied intracellular ROS, a critical component of ferroptosis
