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Senescence-associated beta gal (SA--gal) is another popular laboratory standard for quantifying senescent cells, reflecting the heightened activity and abundance of lysosomal enzymes that enable the cleavage of terminal -d-galactose from -D-galactosides at pH = 6 (Figure 1)

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As we age, the prefrontal cortex the seat of focus, judgment, and working memory is the first region to lose its edge, and the most responsive to targeted intervention