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The GOF mutations are generally known as hotspot mutations, which have a higher occurrence rate than LOF mutations [128, 129]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Manish P., Antonio J., Ding W., Salomon S., Todd B., Randy S., Ravit G., Shivaani K., Patrick R., Ruth P., Patricia L., Shilpa G., Sima Z., Andressa L., Oleg M., Josh F., Sheryl C., Stephanie P., William R., Praveen A., Lisa J., Khanh D., Robert M., Ryan S