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Given the smaller sample sizes available in non-European populations, we did not perform genome-wide association testing in these populations, and instead focused analyses on variants discovered as associated in the European GWAS

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rodentium infection, the activation of IL-1R1 occurs both in ILCs and in GREM+ mesenchymal cells, inducing the production of R-spondin 3 (RSPO3), an intestinal stem cell self-renewal activator

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