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In contrast to conventional spring-based devices that deliver fixed-force profiles and are susceptible to transient pressure spikes, adaptive actuators facilitate smooth initiation and sustained injection flow

Additionally, some patients may experience paradoxical worsening or develop new chemotherapy-induced peripheral neuropathy (CIPN) after BTZ discontinuation, a phenomenon known as coasting, which can lower survival rates, particularly in children and adolescents (Tay et al., 2022

Role for DNA methylation in the control of cell typespecific maspin expression

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In the 1920s, Otto Warburg's observations revealed that tumor cells exhibit enhanced glucose uptake and prefer glycolysis even in the absence of hypoxia, resulting in increased lactic acid production through aerobic glycolysis, known as the Warburg effect [1, 2]