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Although many studies have revealed that PD-1 and programmed cell death-ligand 1 (PD-L1) are highly expressed in HT tissues [34, 48, 79, 80] regardless of whether differentiated thyroid carcinoma (DTC) coexists, it seems to be the response to HT conditions in the immune microenvironment

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(vi) glutamine can promote the synthesis of GABA that stimulates the -catenin pathway, through its receptor, in tumor cells, fostering cellular proliferation (of tumor cells) and impairing CD8 + T cells antitumor activity [188]

The forms of intermittent fasting include three diets: alternate-day fasting (ADF), 5:2 diet, and time-restricted eating (TRE)