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A randomized, double-blind, placebo-controlled, stratified trial of riluzole 100 mg daily, given as 50 mg twice daily, demonstrated a statistically significant survival benefit at 12 and 21 months, with median survival increasing by 83 days [113], with more robust survival effect seen in patients with bulbar onset disease

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In the present study, exogenous GSH enhanced JA signal transduction by inhibiting the expression of genes related to the JAZ protein, thus increasing the levels of JA