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Supplementary Materials Data Availability Statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author/s.

B12 is fundamental to a number of important metabolic processes, including: Red blood cell formation Nervous system function Nutrient absorption Adrenal gland support Cognitive function and memory Brain cell regeneration DNA synthesis Mitochondrial metabolism Male and female reproductive health Because of its important role in the nervous system, severe B12 depletion over time can lead to irreversible neurological damage

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LAZAR allows the prediction of several toxicological endpoints such as mutagenicity, rodent carcinogenicity bloodbrain barrier penetration, and maximum recommended daily exposure of chemicals 34