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glutathione mitochondrial transport Depletion in Diseases Glutathione-coordinated [2Fe–2S] cluster: a viable
Description
Renal interstitium: myofibroblast activation and immunometabolism The core pathological feature of RF is the excessive deposition of collagen-rich ECM in the renal interstitium
![glutathione mitochondrial transport Depletion in Diseases Glutathione-coordinated [2Fe2S] cluster: a viable](https://pubs.rsc.org/en/Content/Image/GA/C4CC09175B)
10.3390/ijms160921486 75 KiokiasS.ProestosC.OrepoulouV
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The specific activity of the Y398A mutant was significantly decreased toward both tyrosine and DOPA
![glutathione mitochondrial transport Depletion in Diseases Glutathione-coordinated [2Fe2S] cluster: a viable](https://www.cell.com/cms/attachment/2009215021/2031834330/gr3.jpg)
Among them, the thiol group (-SH) on the cysteine residue is the key active site through which glutathione performs antioxidant, detoxification, and other functions
![glutathione mitochondrial transport Depletion in Diseases Glutathione-coordinated [2Fe2S] cluster: a viable](https://cdnsciencepub.com/cms/10.1139/bcb-2018-0189/asset/images/large/bcb-2018-0189f10.jpeg)
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