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This leads to further sickness and soon we are in the downward spiral of chronic illness. (Read more here Glutathione The Mother of All Antioxidants.) Even when you get plenty of other antioxidants like Vit C, E, and ALA (Alpha lipoic acid) they may not help much if your master antioxidant, glutathione, falls too low and is unable to be regenerated by your liver due to toxic overload

As a result, plenty of methyl groups are available and cobalamin recycling via SAM is superfluous