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Bile acid therapy for primary biliary cholangitis: Pathogenetic validation

30 , 594606.e3 (2019)

doi: 10.1093/jn/114.10.1762

Higher doses (particularly 54 mg) showed somewhat increased gastrointestinal symptoms compared to lower doses

Pb lead PBG porphobilinogen PBGD porphobilinogen deaminase PBPK physiologically-based pharmacokinetic PPOX protoporphyrinogen oxidase PP protoporphyrin RBC[s] red blood cell[s] Rotor syndrome Rotor syndrome SLC solute carrier TCA tricarboxylic acid Th thallium UBR unconjugated bilirubin UDPGT uridine diphospho-glucuronosyl transferase URO3S uroporphyrinogen 3 synthase UROD uroporphyrinogen decarboxylase Urogen[s] uroporphyrinogen[s] UP[s] uroporphyrin[s] X xenobiotics Zn zinc Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication