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In general, iron overload in cells, decreased GPX4 and xCT expression, activation of acylCoA synthetase long-chain family member-4 (ACSL4) and lysophosphatidylcholine acyltransferase-3, and an increase in lipid peroxidation are the four main mechanisms that induce ferroptosis [82,83,84]

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Due to its strong bond with heme iron, CO inhibits the transport of oxygen in the blood, while interacting with cytochrome c oxygenase and cytochrome p450 it inhibits cellular respiration and promotes tissue death (66)

(The NADPH-producing mitochondrial ME3 is not expressed in the mouse liver)

Nat Rev Mol Cell Biol 12: 152162, 2011
