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pH-responsive bacterial protoplast nanovesicles delivering CRISPR components targeting PIK3CG successfully reprogram TAMs toward an M1 anti-tumor phenotype (293), while inhalable coreshell lipid nanoparticles encapsulating HK2-targeting CRISPR/Cas9 suppress glycolytic metabolism and mitigate hyperinflammation in acute lung injury (294)
JAMA Network Open, 7 (5), e2413172
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More research is needed, but the early clinical outcomes are encouraging, he says
