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Exosomes derived from NSCs significantly increase SIRT1 levels in AD mice, enhance mitochondrial biogenesis, and inhibit astrocyte activation (Li et al., 2024)
Despite the optimism, the field must navigate significant challenges
[DOI] [PMC free article] [PubMed] [Google Scholar] 440.Hjorth E, et al
Safinamide possess anti-glutamatergic effects and also acts as MAO-B inhibitor
This intervention led to clinically meaningful improvements in fatigue, sleep quality, and functional well-being without any adverse events, further supporting the safety and acceptability of exercise during active treatment [228]
