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In contrast, upregulation of CD38 expression was evident on pp65 495503 specific CD8 + T cells of noncontrollers (Figure 5A), which was even more pronounced in individuals who were at high risk for CMV (Supplemental Figure 5A)

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Researchers are now applying similar allosteric targeting strategies to the glucagon receptor, the GIP receptor, the PTH receptor, and the calcitonin receptor