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FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma
Its main role is to reduce NADP+ to NADPH at the expense of NADH oxidation and H+ re-entry to the mitochondrial matrix
[DOI] [PMC free article] [PubMed] [Google Scholar] [74].Pratico D
Hence, molecular oxygen propagates free radical damage and has a central role in oxidative stress
