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Superoxide Dismutase (SODs) Superoxide dismutase (SODs) is vital to cellular health, protecting cells from oxidative damage
10.1016/j.molcel.2013.04.021 Mol
A recent study has demonstrated that an acute increase in the intracellular concentration of ROS inhibits the glycolytic enzyme pyruvate kinase M2 (PKM2) through the oxidation of Cys358 ( NRF2 INHIBITORS FOR ANTICANCER THERAPY Due to the multifaceted roles of Nrf2 in cancers, Nrf2 inhibitors could be effective for anticancer therapy
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On the other hand, free radicals directly degrade the joint cartilage by targeting its proteoglycan and restricting its synthesis
