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The kidneys are responsible for filtering the blood from harmful metabolites, and long-term ketosis can result in hypercalciuria, as a result of which kidney stones can accumulate in the organ 13

This is in very severe cases

It is a nutrient that is water soluble

In Shi et al, Lactobacillus rhamnosus GG (LGG) was shown to modulate T-bet expression and Th1 differentiation via two metabolite-mediated pathways regulation of T-bet, EPS engage the TLR2/MyD88 dendritic cell pathway with subsequent production of IL-12 and resultant STAT4 phosphorylation that directly amplifies T-bet, and SCFAs, such as butyrate, repress histone deacetylases (HDACs), enhancing Tbx21 promoter acetylation to increase T-bet expression

Preservation of Neurovascular Unit Integrity The integrity of the blood brain barrier (BBB) and neurovascular units (NVU) cellular function is essential for CNS homeostasis via the regulation of influx/efflux transport and neurovascular coupling, ensuring adequate cerebral perfusion, while providing a protective barrier against potentially harmful molecules in the peripheral circulation [225]