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Description
SEPS1 contributes to the removal and transfer (retrotranslocation) of misfolded proteins from the ER lumen to the cytosol where proteins are tagged with ubiquitin before being degraded
Prominent examples include oxytocin known for its positive effects on social behaviour and autism [161,162,163] as well as orexin-A improving the CNS hypocretin signalling and olfaction and thus offering a possible treatment for narcolepsy [164,165,166]
Oncotarget (2014) 5:79823.10.18632/oncotarget.2352 36 ValenciaTKimJYAbu-BakerSMoscat-PardosJAhnCSReina-CamposMet alMetabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis
Some individuals may experience mild side effects such as gastrointestinal discomfort
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