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doi: 10.1016/s0047-6374(00)00235-9
GSH production is supported by NRF2 through controlling several enzymes responsible for GSH synthesis, such as the glutamate-cysteine ligase (GCL) complex composed of two subunits, the modifier (GCLM) subunit and the catalytic (GCLC) subunit, which catalyze the rate-limiting step of GSH synthesis that converts cysteine and glutamate into GSH [22]
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Figure 8 Eleven samples were available for the immunoblot assay ( Figure 9 )
Dosing for confirmed deficiency: 500 to 1,000 mcg per day orally
