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Mechanistically, NOX2/ROS induces endothelial-derived ET-1 overexpression, which activates the ERK1/2 signaling pathway to mediate the shift of microglia activation to a pro-inflammatory M1 phenotype that triggers the release of inflammatory mediators

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In addition to these medically important genera, the Ajellomycetaceae family also includes more rarely observed pathogenic species including Emmonsia parva and Ea

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