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Even though a 48-h NAC treatment has been associated with about a 50-fold decrease in HBV assembly in HepG2-A5 cells [247], NAC has been revealed to be ineffective in acute viral B hepatitis treatment [287], However, other studies reported that NAC alone or in combination with other antiviral had no effects on plasma concentration of GSH, SOD and CAT for HBV [288,289] or HCV [290]

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