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In one small-scale case study, OAB patients showed increased urine IL-10 levels compared with controls 15

Both FM and functional gastrointestinal disorders (FGIDs) are thought to be linked to dysfunction of autonomic nervous system, which can lead to central sensitization, and may have a mutual reinforcing effect [30, 31]

10.1016/j.freeradbiomed.2017.10.009 Free Radic

Technical Limitations A major limitation of current VNS technology is its inability to selectively stimulate functionally distinct fibers within the VN: it activates a mix of vagal fibers (both afferent and efferent) based largely on fiber size and threshold, rather than targeting specific pathways

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