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Cell Biology Toxicology 39 (6), 26852707

Following OA induction, the rabbits were randomly divided into four groups with 8 subjects, each receiving a different weekly intra-articular treatment starting four weeks after the first collagenase injection

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A consultation with an independent specialist will determine whether a single modality or a combined protocol represents the best treatment for your individual concerns

Initial Treatment/Dose Adjustment (Adults) Treatment with clomipramine should be initiated at a dosage of 25 mg daily and gradually increased, as tolerated, to approximately 100 mg during the first 2 weeks