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doi:10.14219/jada.archive.2012.0020 Cotler HB, Chow RT, Hamblin MR, Carroll J

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FcRn antagonists likely block transplacental transport of IgG, as demonstrated for nipocalimab in an ex vivo placental transfusion model [341], and are unlikely to pass to the fetus, as the high affinity and limited pH-dependency of their binding to FcRn cause them to stay within FcRn-expressing cells, and not undergo extensive receptor-mediated transport