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Signs and symptoms One primary symptom of B12 deficiency is fatigue a level of tiredness or exhaustion so deep that it affects daily life activities

If the doctor suspects imbalances due to conditions like muscle weakness, weight loss, or anaemia, they may recommend this test

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But in fact, the term pernicious anemia means a specific vitamin B12 deficiency caused by the loss of the bodys ability to make intrinsic factor. Intrinsic factor is in the lining of the stomach, so a weakened stomach lining (which is called atrophic gastritis can cause pernicious anemia