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The phosphoinositide-3-kinase (PI3K)/Akt axis participates in a multitude of intracellular processes, such as those involved in protein synthesis, cell proliferation and death, and autophagy, and also in the development of drug tolerance upon stimulation by cytokines and growth factors (GFs) (84)

Blots were incubated with HRP-conjugated secondary antibodies (BS13278, Bioworld Technology Inc., MN, USA) for 1 h, and protein expression was detected with ECL (WBULS0500, Millipore, MA, USA) by digital imaging systems (SYNGENE, Cambridge, UK)

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The pretreatment of cultured rat hepatocytes with UDCA significantly prevents the decrease in viability due to H 2 O 2 or cadmium administration [77]

(168) reported markedly raised blood TMAO levels in PMW with hip fractures, suggesting that heightened TMAO may be associated with an increased risk of OP and fracture in this population