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The response of spinal microglia to chemotherapy-evoked painful peripheral neuropathies is distinct from that evoked by traumatic nerve injuries

The oxidative branch of the pentose phosphate pathway (PPP), driven primarily by the enzymes glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD), continues to serve as the dominant metabolic source of NADPH in most cells [42]

Hesperidin may cause sedation and drowsiness, which could be exacerbated when combined with CNS depressants

[DOI] [PubMed] [Google Scholar] 366.Yin K., Agrawal D.K

This leads to a six-membered transition state involving two hydroxyl groups of Thr399 and Thr417 and one carbonyl group of Gln398