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Acknowledgements This study comprised the thesis for a master degree in Biochemistry and Molecular Biology at the University of Indonesia

As a powerful antioxidant, glutathione is essential for maintaining healthy cells

Interestingly, a follow-up study found that neither pre- nor post-treatment of metformin against APAP hepatotoxicity inhibited JNK activation or its mitochondrial translocation [31], [32]

Studies often focus on receptor-mediated signaling dynamics and their potential association with cellular metabolic regulation, protein turnover processes, and neuroendocrine feedback mechanisms, as described in cell-based and animal research literature

Another important aspect related to the crosstalk between GSH and NO refers to the antioxidant function