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W., Savelkoul H
To date, at least 40 genes have been linked to ALS [7], with only a subset felt to be directly causative
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While evidence indicates that elevated levels of soluble UA, independent of MSU crystals, directly influence the development and progression of neurological disorders, soluble UA showed robust antioxidative and anti-inflammatory effects [9]
The cooperativity of SOD, CAT, and peroxidases ensures low amounts of superoxide anion and H 2 O 2 and limiting the risk of hydroxyl radical formation (Figure 5)
