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Clinical studies have shown that MDA levels in serum and plasma samples of MASLD patients are significantly higher than in healthy individuals [133]

Acad Radiol 21(1):6471

A marked reduction was observed in protective phyla, including Bacteroidota, which was significantly decreasedcompromising SCFA production and gut homeostasisalong with a substantial depletion of Actinomycetota, a phylum containing Bifidobacterium, indicating impaired immunomodulatory capacity

Interestingly, knockout of IRE1 in CT26 colon cancer cells had a minimal effect on tumor growth in syngeneic mice, whereas systemic pharmacological inhibition of IRE1 significantly suppressed tumor progression

H., Ruigrok, S