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Description
Age As individuals age, the body's ability to absorb vitamin B12 declines
Chronic use of these medications without concurrent glutathione support may contribute to long-term oxidative stress accumulation and cellular dysfunction
these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Specific titration approaches vary by compound

For this reason, testing and clinical assessment are recommended before treatment
