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While recognition of its heterogeneity has driven a paradigm shift toward precision medicine, tailoring multimodal strategies to the dominant pain mechanism, critical challenges persist

Traditionally, TRT has been administered via injections, gels, or patcheseach with their own pros and cons

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Thus, therapeutic reinforcement of the NAD + system has been proposed as a potential prophylaxis approach against viruses such as SARS-CoV-2 infection 62