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doi: 10.1016/j.det.2009.10.023 59 WaksalJAMascarenhasJ

Subjects were excluded from l-carnitine or BB challenge testing if they were pregnant, had chronic illness (including a known history of heart failure, renal failure, pulmonary disease, gastrointestinal disorders, or hematologic diseases), had an active infection, received antibiotics within 2 months of study enrollment, used any over-the-counter or prescription probiotic or bowel-cleansing preparation within the past 2 months, ingested yogurt within the past 7 days, or had undergone bariatric or other intestinal (e.g., bowel resection/reconstruction) surgery
At 72 weeks, participants on 15mg lost an average of 22.5% body weight compared to 2.4% in the placebo group
Acetyl-L-carnitine is an orally active mitochondrial energy metabolism regulator and neuroprotectant that can penetrate the blood-brain barrier
We used the Clopper-Pearson method to calculate point estimates and two-sided 95% exact confidence intervals for rates of sustained virologic response for the sofosbuvir-velpatasvir group as a whole, as well as according to HCV genotype (1a, 1b, 2, 4, 5, or 6), and various subgroups
