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De Santis, M

One study suggested that drugs such as metformin can rebalance myeloid metabolism and suppress chronic inflammation, showing potential in ART-treated PWH and associated immune ageing, although the long-term effects remain uncertain [55]

Although this adaptation is beneficial in hypoxia, it is deleterious when RBCs are challenged by oxidant stress, such as during refrigerated storage in the blood bank [103] or in sickle cell disease, where deoxy-sickle hemoglobin stabilization further promotes its crystallization [102]

This reduction may theoretically lessen inflammation and oxidative stress in impacted tissues

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