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The mechanism by which this detoxification occurs is through the addition of GSH to the harmful compounds via a reaction at an electrophilic residue and the sulfhydryl residue of GSH [90]

The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]

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Comn-AnduixBBorenJMartinezSMoroCCentellesJJTrebukhinaRet al