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Other pharmacological options include catechol-O-methyltransferase (COMT) inhibitors like entacapone and opicapone, which extend the half-life of levodopa, do not cross the BBB at all and primarily affect peripheral metabolism, providing no direct action in the brain 59

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It is another reason to think that there is something else going on besides the KIT gene mutations.[ref] Mast Cell Leukemia: Advanced mast cell disorders include a type of leukemia called mast cell leukemia

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