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In summary, the inflammatory microenvironment in IDD is extremely complex, with different cytokines and proteases regulating the survival, proliferation, migration, and differentiation fate of MSCs and disc progenitor cells in a concentration- and cell-dependent manner
After puberty, the male hormone testosterone surges, hence DHT surges
Their expression is tissue-dependent, whereas GPx1 is found in red cells, liver, lung, and kidney, GPx2 is found in gastrointestinal tracts, GPx3 is present in different organs such as kidney, lung, epididymis, vas deferens, placenta, seminal vesicle, heart and muscle and GPx4 which is widely distributed in various tissues [30]
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