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Most reports show that the over-accumulation of NO is induced under Cd exposure 15,18

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Gerontology, 55:64-72

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Notably, the activation of HIF1 occurs in the absence of adequate oxygen or vitamin C supply

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In particular, the renal-type GLS-1 form disrupts GLN-driven oxidative phosphorylation in AML cell lines, thereby preventing tumor growth and inducing apoptosis [55]

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