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Follow-up began upon entry into the study and ended on the date of detection of an abnormal value of a biochemical marker or of the final follow-up, whichever was sooner

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This model suggests that analyte ions can be generated either as primary ions during the proton-transfer process between the matrix and the analyte, matrix + analyte [matrix-H] + [analyte+H] + , or as secondary ions through subsequent ion-molecule reactions

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