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When mitochondrial glutathione is depleted, energy production becomes less efficient and mitochondrial DNA accumulates mutations a process associated with aging and age-related diseases

10.1053/j.gastro.2019.01.249 91 VosoughiK.IchkhanianY.JacquesJ.AadamA

For the H 2 O 2 RNA-seq experiments in MCF7 cells after reexpression of 6KR MED1 or 6KQ MED1, spike-in controls were used

Animal feeding with a high-fat diet increased metastasis rates and local invasion of prostate cancer in transgenic adenocarcinoma of mouse prostate mice, suggesting the circulating cytokine and adipokine alterations in response to excess adipose tissue deposition induced by a high-fat diet may enhance prostate cancer progression [42]

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