importance of glutathione peroxidase The Selenoprotein 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Selective Small-Molecule Activator of Patient-Derived
Description
After nuclear factor kappa B (NF-kB) activates glutaminase C isoform (GAC), an alternatively spliced isoform of GLS1, via phosphorylation, NF-kB itself is activated by Rho GTPases
When tolerance is lost, these cells can drive chronic inflammation, autoantibody production, and tissue damage (Hampe 2012)
doi: 10.1007/s00401-013-1242-2, 33
Melnyk S, Jernigan S, Savenka S, James SJ: Elevation in S-adenosylhomocysteine and DNA hypomethylation in parents and children with autism
Anesthesiology 86, 549557
