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Activation of beta-3 adrenergic receptors stimulates adenylyl cyclase, an enzyme that converts ATP to cyclic AMP (cAMP)

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Accordingly, DOPAC in CSF is predicted to be a PD biomarker and can sensitively distinguish between PD patients ( 3.3 Lysosomal enzyme biomarkers The two primary degradation mechanisms in the human body are the lysosomal and proteasome systems
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Funding Statement The authors gratefully acknowledge the financial support provided by the Fundao Carlos Chagas de Amparo Pesquisa do Estado do Rio de Janeiro, Brazil, grant numbers [E-26/203.745/2024] and [E-26/200.891/2021], the Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq), grant number [313119/2020-1], and the Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES) Brazil, Finance Code 001
