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Interestingly, the single-therapy groups scored almost exactly the same, with fluoxetine at 64.7% and curcumin at 62.5% numbers so close that the difference is not statistically significant from one another

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Genes strongly up- or down-regulated (FDR 0.01) according to Cuffdiff, with an age-related fold change 1.5 and an FPKM 1 in either young or old, were analyzed for functional annotation enrichment using DAVID Functional Annotation Tool ( Genes with significant (FDR 0.05) disparities in expression between biological replicates according to Cuffdiff were excluded