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The cystic and necrotic characteristics aligned with known patterns of aberrant angiogenesis in metastatic MPNST but also necessitated differentiation from vascular lesions related to infectious etiologies ( The pathological diagnosis of MPNST requires the integration of histomorphology, immunophenotyping, and molecular profiling
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It is to be noted that the dosing used in this trial (1000 mg/d) was lower than doses used in trials where significant differences were seen
