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Astra galus membranaceus-Salvia miltiorrhiza can also be driven by Akkermansia muciniphila and Lactobacillus murinus, regulates target metabolites such as 1acylsnglycero3phosphocholine and phospho1, modulates pathways related to glucose and lipid metabolism, and thereby ameliorates diabetic nephropathy through the gutkidney axis [172]

A careful retrospective analysis of all the patients involved in the clinical studies did not find any new progressive multifocal leukoencephalopathy cases

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HO-1 regulated immune balance by reducing the expression of pro-inflammatory T H 1 cytokines towards a beneficial T H 2 pattern, restoring T reg cell responses in diabetic mice and T2DM patients [48, 49]