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Moreover, loss-of-function mutations of succinate dehydrogenase (SDH) increase cellular succinate level, which inhibits DNA demethylation and contribute to tumorigenesis [62,63]

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1,2 Amino acid metabolism disorders have been linked to the progression of various diseases

Carcinogenesis 6:173545 Hoffer E, Baum Y, Tabak A, Taitelman U (1996) N -acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity