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These reactions are generally harmless but uncomfortable

DN is pathologically characterized by mesangial matrix thickening, progressive destruction of glomerular and tubulointerstitial, and loss of functioning glomeruli, ultimately leading to chronic renal failure [138, 139]

Additionally, Baldwin and Kiick reported that NEM adducts of some thiols including N -acetylcysteine may undergo retro and exchange reactions at physiological pH and temperature [45]

Exclusion criteria included significant medical or neurological conditions, major psychiatric disorders, a history of traumatic brain injury with loss of consciousness, and contraindications to brain MRI

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent
